Recombinant SIN3A Monoclonal Antibody

SKU: AN302059L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:SIN3A

Target Synonym:SIN3A;WITKOS

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A779

UNIProt ID:Q96ST3

Accession:

Background:onBackground Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYConcogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperativelywith OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for thetranscriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for corticalneuron differentiation and callosal axon elongation.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:2000;IHC 1:100-1:1000;IP 1:50-1:100

Calculated MW:145 kDa

ObservedMW:150 kDa