Recombinant RUNX3 Monoclonal Antibody

SKU: AN301806L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:RUNX3

Target Synonym:AML;RUNX;CBFA;Oncogene AML;Core-binding factor subunit alpha;Runt-related transcription factor;PEBP2A;RUNX3;AML2;CBFA3;PEBP2aC;Acute myeloid leukemia 2 protein;Core-binding factor subunit alpha-3;Oncogene AML-2;Runt-related transcription factor 3;PEBP2A3

Research Areas:Epigenetics and Nuclear Signaling;Neuroscience;Stem Cells;Cancer;Developmental Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A518

UNIProt ID:Q13761

Accession:

Background:RUNX3 is a member of the Runt family of transcription factors, playing an important role in the suppression of gastric epithelium cell proliferation, dorsal root ganglia neurogenesis, and T cell differentiation. RUNX3 is also involved in Caspase-3-dependent apoptosis. Protein complexes containing RUNX3 and various transcription factors, such as Smads or β-catenin/TCF4, have tumor suppressor activity and regulate downstream target gene transcription. While typically localized to the nucleus, RUNX3 can be tyrosine phosphorylated and located in the cytoplasm of many cancer cells. This mislocalization of RUNX3 abolishes its tumor suppressor function and contributes to tumorigenesis.

Concentration:1 mg/mL

Immunogen:Recombinant human RUNX3 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IP 1:25-1:50

Calculated MW:46 kDa

ObservedMW:44-46 kDa