Recombinant Rhesus Macaque IP-10/CXCL10 protein

SKU: CD00031

Size:5 ug

Background:CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene. CXCL10 was originally identified in monocytes, endothelial cells and fibroblasts as a responsor to IFN-γ. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such as promotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. The rhesus macaque IP-10 shares 96 %, 68 %, 74 % a.a. sequence identity with human, Mouse, rat IP-10, respectively.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Rhesus Macaque gamma-Interferon Inducible Protein 10/CXCL10

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood T-lymphocytes is in a concentration range of 1-5 ng/ml.

Synonyms:IP-1/CXCL1, Monkey

Endotoxin:Less than 1 EU/μg of rRhIP-10/CXCL10 as determined by LAL method.

Storage:-20ºC

Sequence:IPLSRTVRCT CISISNQPVN PRSLEKLEII PPSQFCPHVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

uniprot accession:AAD9QX95

Molecular weight:Approximately 8.7 kDa, a single non-glycosylated polypeptide chain containing 77 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.