Recombinant RBBP7/RBBP4 Monoclonal Antibody

SKU: AN302067L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:RBBP7/RBBP4

Target Synonym:RBAP46;RBAP48

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;FCM;ChIP;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A787

UNIProt ID:Q16576;Q09028

Accession:

Background:Retinoblastoma-associated proteins 46 and 48 (RBAP46 and RBAP48, also known as RBBP7 and RBBP4), were first identified in humancells as proteins that bind to retinoblastoma (Rb) tumor suppressor proteins. Since then, these proteins have been shown to be componentsof a number of protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF-1) complex and the Btype histone acetyltransferase complex, HAT1, both of which are involved in chromatin assembly during DNA replication. RBAP46 andRBAP48 are also present in the nucleosome remodeling factor complex, NURF, and the nucleosome remodeling and histone deacetylationcomplex NuRD, and the Sin3/HDAC histone deacetylation complex. Recently, RBAP46 and RBAP48 were identified as components of thepolyribonucleic acid repressor complex PRC2, which also contains EED and Ezh2. RBAP46 and RBAP48 bind to the histone folding regionof histone H4 and are thought to target these chromatin remodeling, histone acetylation and histone deacetylation complexes to their histonesubstrates.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:10000-1:20000;IHC 1:500-1:1000;FCM 1:100;ChIP 6 μg/2×10⁶ cells;IP 1:50-1:100

Calculated MW:48 kDa

ObservedMW:50 kDa