Recombinant PLAG1 Monoclonal Antibody

SKU: AN301944L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:PLAG1

Target Synonym:ZNF;Zinc finger protein PLAG;Pleiomorphic adenoma gene;FGFR1/PLAG1 fusion variant;PLAG;COL1A2/PLAG1 fusion;FGFR1/PLAG1 fusion variant 3;Pleiomorphic adenoma gene 1;Pleiomorphic adenoma gene 1 protein;PSA;SGPA;Zinc finger protein PLAG1;ZNF912;PLAG1;PSA;SGPA

Research Areas:Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A660

UNIProt ID:Q6DJT9

Accession:

Background:Pleiomorphic adenoma gene 1 protein (PLAG1) is a transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. When PLAG1 overexpression in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. PLAG1 ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. PLAG1 overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. PLAG1 cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.

Concentration:1 mg/mL

Immunogen:Recombinant human PLAG1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:5000-1:10000;IHC 1:50

Calculated MW:56 kDa

ObservedMW:56 kDa