Recombinant Phospho-MEK1 (Thr292) Monoclonal Antibody

SKU: AN302097L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies;Acetyl/Phospho/Methyl Antibodies

Abbreviation:Phospho-MEK1 (Thr292)

Target Synonym:MEK;MKK;CFC;MAPKK;PRKMK;MAP2K;CFC3;MAPKK1;MEK1;MKK1;PRKMK1;MAP2K1;Dual specificity mitogen activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 1;ERK activator kinase 1;kinase 1;MAP kinase kinase 1;MAP kinase/Erk kinase 1;MAPK/ERK kinase 1;MAPKK 1;MEK 1;MEKK1;Mitogen activated protein kinase kinase 1;MKK 1;MP2K1;Protein kinase mitogen activated;Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1)

Research Areas:Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A821

UNIProt ID:Q02750

Accession:

Background:MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx. Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells. MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000

Calculated MW:43 kDa

ObservedMW:43 kDa