Recombinant Phospho-JNK1, 2, 3 (Thr183, Thr183, Thr221) Monoclonal Antibody

SKU: AN301149L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Acetyl/Phospho/Methyl Antibodies;Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:JNK1, 2, 3

Target Synonym:MAPK;PRKM;SAPK;JNK1A;JNK21B;MAPK8;JNK;JNK-46;JNK1;JNK1A2;JNK21B1/2;PRKM8;SAPK1;SAPK1c;AI849689;c Jun N terminal kinase 1;C-JUN kinase 1;c-Jun N-terminal kinase 1;EC 2.7.11.24;JNK 1;MAP kinase 8;MAPK 8;Mitogen activated protein kinase 8;mitogen-activated;Mitogen-activated protein kinase 8;MK08;p54 gamma;Protein kinase;Protein kinase JNK1;SAPK 1;SAPK gamma;Stress-activated protein kinase 1;Stress-activated protein kinase JNK1;JNK1/2/3

Research Areas:Signal Transduction;Cancer;Immunology;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6H10

UNIProt ID:P45983;P45984;P53779

Accession:

Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

Concentration:0.2 mg/mL

Immunogen:A synthetic peptide corresponding to residues around (Thr183, Thr183, Thr221)of Human Phospho-JNK1, 2, 3

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;

Calculated MW:48 kDa

ObservedMW:46,54 kDa