Recombinant Phospho-Chk1 (Ser345) Monoclonal Antibody

SKU: AN301324L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Acetyl/Phospho/Methyl Antibodies;Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Chk1

Target Synonym:CHK;CHEK;CHEK1;CHK1

Research Areas:Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:9C1

UNIProt ID:O14757

Accession:

Background:The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Concentration:0.2 mg/mL

Immunogen:A synthetic peptide corresponding to residues around (Ser345) of Human Phospho-Chk1

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:500-1:2000;

Calculated MW:56 kDa

ObservedMW:56 kDa