Recombinant Phospho-Caveolin-1 (Tyr14) Monoclonal Antibody

SKU: AN302089L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies;Acetyl/Phospho/Methyl Antibodies

Abbreviation:Phospho-Caveolin-1 (Tyr14)

Target Synonym:PPH;CGL;BSCL;MSTP;cell growth-inhibiting protein;OTTHUMP;VIP;BSCL3;CGL3;LCCNS;MSTP085;PPH3;VIP21;CAV1;22 kD;caveolae protein;caveolin 1 alpha isoform;caveolin 1 beta isoform;Caveolin 1 caveolae protein 22kDa;Caveolin1;Caveolin-1;cell growth-inhibiting protein 32;OTTHUMP00000025031;VIP 21;CAV

Research Areas:Cardiovascular;Signal Transduction;Tags & Cell Markers;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A813

UNIProt ID:Q03135

Accession:

Background:Caveolins are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease. Caveolins interact with multiple signaling molecules, such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7. Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway.

Concentration:1 mg/mL

Immunogen:phosphorylated human Caveolin-1 (Tyr14) peptide

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000

Calculated MW:20 kDa

ObservedMW:22 kDa