Recombinant Pancreasin/Marapsin/PRSS27 Monoclonal Antibody

SKU: AN300100P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:PRSS27

Target Synonym:UNQ;PRO;UNQ1884/PRO;Prss;CAPH;CAPH2;UNQ1884/PRO4327;MPN;PRSS27;UNQ1884;PRO4327

Research Areas:Cell Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IP

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:11G3

UNIProt ID:Q9BQR3

Accession:

Background:The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most strongly up-regulated protease in psoriatic lesions, where expression was localized to the upper region of the hyperplastic epidermis. Similarly, in the hyperproliferative epithelium of regenerating murine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous differentiation. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.

Concentration:1 mg/mL

Immunogen:Recombinant Human Pancreasin / Marapsin / PRSS27 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IP 4-6 μL/mg of lysate

Calculated MW:32 kDa

ObservedMW:32 kDa