Recombinant Mouse IL-36RA protein

SKU: CD00357

Size:2 ug

Background:Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1 family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes.IL-36RA has been reported to antagonize the biological activity of IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). Furthermore, it could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirect evidence suggests it is IL-1Rrp2. Recombinant Mouse interleukin-36 RA contains 154 amino acid residues and it shares 91 % a.a. sequence identity with human IL-36RA.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Interleukin-36 Receptor Antagonist Protein

Biological activity:Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.

Synonyms:Il36rn,AI413231, FIL1d, Fil1delta, IL-1, IL-36Ra, IL1, IL1H, If36rn, Il-1h3, Il1f5, Il1hy1, Mouse

Endotoxin:Less than 1 EU/μg of rMuIL-36RA as determined by LAL method.

Storage:-20ºC

Sequence:VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD

uniprot accession:Q9QYY1

Molecular weight:Approximately 16.9 kDa, a single non-glycosylated polypeptide chain containing 154 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.