Recombinant Mouse IL-21 protein

SKU: CD00368

Size:2 ug

Background:Mouse IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells. It promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 elicits its effect through binding IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. IL-21 shows having much relation with clinical illnesses, including cancer immunotherapy, viral infections and allergies.

Research_area:Immunology

Purity:> 98 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Interleukin-21

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of > 4. × 14 IU/mg.

Synonyms:IL-21, IL21,Mouse

Endotoxin:Less than 0.1 EU/μg of rMuIL-21 as determined by LAL method.

Storage:-20ºC

Sequence:HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DLDPELLSAP QDVKGHCEHA AFACFQKAKL KPSNPGNNKT FIIDLVAQLR RRLPARRGGK KQKHIAKCPS CDSYEKRTPK EFLERLKWLL QKMIHQHLS

uniprot accession: Q9ES17;E9PX58;Q5SUE2

Molecular weight:Approximately 15. kDa, a single non-glycosylated polypeptide chain containing 129 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 × PBS, pH 7.4.