Recombinant Mouse CD40/TNFRSF5 Protein(His Tag)

SKU: PDMM100170

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Immune Checkpoint Proteins

Abbreviation:CD40/TNFRSF5

Target Synonym:IMD;B-cell surface antigen CD;Tumor necrosis factor receptor superfamily member;HIGM;Tnfrsf;HIGM1;I326936;IGM;IMD3;p50;T-BAM;TRAP;Bp50;CD40;Tnfrsf5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;CD40L receptor;gp39 R; TNFRSF5;CD40 (protein);CD40 molecule;CDW40

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:P27512

Accession:P27512

Background:CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thoμght to be an early event in Alzheimer disease pathogenesis.

Concentration:

Activity:Not validated for activity

Sequence:Leu20-Arg193

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:19 kDa

ObservedMW:30 kDa