Recombinant MDM2 Monoclonal Antibody

SKU: AN300707L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:MDM2

Target Synonym:hdm;MDM;MDM2;ACTFS;HDMX;hdm2;Double minute 2 protein;E3 ubiquitin-protein ligase Mdm2;Hdm 2;MDM 2;MDM2 oncogene E3 ubiquitin protein ligase;Mdm2 p53 E3 ubiquitin protein ligase homolog;Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa;MDM2BP;Mouse Double Minute 2;MTBP;Murine Double Minute Chromosome 2;Oncoprotein Mdm2;p53 Binding Protein Mdm2;p53-binding protein Mdm2;Ubiquitin protein ligase E3 Mdm2

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:11D16

UNIProt ID:Q00987

Accession:

Background:This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human MDM2 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:55 kDa

ObservedMW:90 kDa