Recombinant KLK8/Kallikrein 8 Monoclonal Antibody

SKU: AN300243P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:KLK8

Target Synonym:KLK;UNQ;PRO;Kallikrein;Serine Protease;TADG;PRSS;Serine Protease TADG;hK8;Kallikrein-8;Neuropsin;NP;Ovasin;Serine Protease 19;Serine Protease TADG-14;Tumor-Associated Differentially Expressed Gene 14 Protein;NRPN;PRSS19;TADG14;KLK8;UNQ283;PRO322;Brain serine protease 1;BSP1;HNP;homolog of;HPN;included;Kallikrein 8 (neuropsin/ovasin);Kallikrein related peptidase 8;Kallikrein8;KLK 8;KLK8 protein type 1;KLK8 protein type 2;mouse;neuropsin type 1;Neuropsin type 2;Protease serine 19;PRSS 19;Serine protease kallikrein;Serine protease kallikrein/ovasin/neuropsin;Serine protease TADG 14;Serine protease TADG14;TADG 14;Tumor associated differentially expressed gene 14;Tumor associated differentially expressed gene 14 protein

Research Areas:Signal Transduction;Cancer;Cell Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Monoclonal

Clone NO.:5F6

UNIProt ID:O60259

Accession:

Background:Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8/KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. It regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Kallikrein-8/KLK8 is expressed at high levels in serum, ascites fluid, and tumor cytosol of advanced-stage ovarian cancer patients and may serve as a marker of ovarian cancer. Kallikrein-8/KLK8 may have potential clinical value for disease diagnosis or prognosis and it may also be a useful therapeutic target.

Concentration:1 mg/mL

Immunogen:Recombinant Human KLK8 / Kallikrein 8 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;

Calculated MW:28 kDa

ObservedMW:35 kDa