Recombinant IGFBP6/IBP6 Monoclonal Antibody

SKU: AN300520N

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:IGFBP6

Target Synonym:IGF-binding protein;IGF binding protein;ERBB;ErbB1;ErbB-1;IBP6;IGF binding protein 6;Insulin-like growth factor-binding protein 6;mENA;IBP-6;IGFBP-6;IGF-binding protein 6;IGFBP6

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse

Application:IHC-P

Isotype:IgG

Clonality:Monoclonal

Clone NO.:9A8

UNIProt ID:P47880

Accession:

Background:The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Mouse IGFBP-6 cDNA encodes a 238 amino acid (aa) residue precursor protein with a putative 25 aa residue signal peptide that is processed to generate the 213 aa residue mature protein that is O-glycosylated. Mouse and human IGFBP-6 share 73% amino acid similarity. Mouse and rat IGFBP-6 share 94% amino acid similarity and the mouse IGFBP-6 has a 9 amino acid insertion compared to the rat homolog. IGFBP-6 is expressed in ovarian, testicular, muscle, heart and lung tissues in the adult mouse. IGFBP-6 was not detected in total RNA from a whole mouse embryo.

Concentration:1 mg/mL

Immunogen:Recombinant Mouse IGFBP6/IBP6 Protein

Buffer:0.2 μm filtered solution in 20 mM MES, 100 mM NaCl, 10% Trehalose, pH 6.0

Purification method:Protein A

Dilution:IHC-P 1:100-1:500

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