Recombinant Human T-cell leukemia virus 1 HTLV-1 basic zipper factor (HBZ)

SKU: P0C745

Size: 100ug. Other sizes are also available.

Activity: Not tested

Research Areas: Others

Uniprot ID: P0C745

Gene Names: HBZ

Alternative Name(s): (HBZ)

Abbreviation: Recombinant Human T-cell leukemia virus 1 HBZ protein

Organism: Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)

Source: E.coli

Expression Region: 1-209aa

Protein Length: Full Length

Tag Info: N-terminal 6xHis-tagged

Target Protein Sequence: MVNFVSVGLFRCLPVPCPEDLLVEELVDGLLSLEEELKDKEEEETVLDGLLSLEEESRGRLRRGPPGGKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGVDGYTRQLEGEVESLEAERRRLLQEKEDLMGEVNYWQGRLEAMWLQ

MW: 29 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Endotoxin: Not test

Biological_Activity:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Relevance: Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes. Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation. Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells. Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway. Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis.

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Function: