Recombinant Human Neuroserpin protein

SKU: CD01225

Size:5 ug

Background:Neuroserpin encoded by the SERPINI1 gene in humans is a member of the serine proteinase inhibitor (serpin) family. It reacts preferentially with tissue-type plasminogen activator (tPA). Neuroserpin is expressed mainly in the central nervous system (CNS) in response to neuronal depolarization and plays an important role in the development of synaptic plasticity. Mutations in human neuroserpin result in a form of autosomal dominant inherited dementia which is characterized by the presence of intraneuronal inclusion bodies and is known as Familial Encephalopathy with Neuroserpin Inclusion Bodies.

Research_area:Others

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Neuroserpin

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by a cell proliferation assay using rat C6 cells is less than .5 μg/ml, corresponding to a specific activity of > 2 IU/mg.

Synonyms:SERPINI1,HNS-S1, HNS-S2, PI12, Neuroserpin, Human

Endotoxin:Less than 1 EU/μg of rHuNeuroserpin as determined by LAL method.

Storage:-20ºC

Sequence:TGATFPEEAI ADLSVNMYNR LRATGEDENI LFSPLSIALA MGMMELGAQG STQKEIRHSM GYDSLKNGEE FSFLKEFSNM VTAKESQYVM KIANSLFVQN GFHVNEEFLQ MMKKYFNAAV NHVDFSQNVA VANYINKWVE NNTNNLVKDL VSPRDFDAAT YLALINAVYF KGNWKSQFRP ENTRTFSFTK DDESEVQIPM MYQQGEFYYG EFSDGSNEAG GIYQVLEIPY EG

uniprot accession:Q99574;C9JDY5;H7C5T9;C9JQU8

Molecular weight:Approximately 44.7 kDa, a single non-glycosylated polypeptide chain containing 394 amino acid residues.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.