Recombinant Human MEC/CCL28 protein

SKU: CD01307

Size:5 ug

Background:CCL28 belongs to CC family chemokine, also named mucosae-associated epithelial chemokine (MEC). The CCL28 cDNA is located on Chr.5 in humans, and the mRNA of CCL28 is highly expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. The amino acids sequence of human and mouse CCL28 shares 83 % identity, when the protein is processed to be the mature form. CCL28 is signaling through CCR3 and CCR10, and chemotactic for resting CD4, CD8 T-cells and eosinophils.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Mucosae-associated Epithelial Chemokine/CCL28

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 1.-1. ng/ml.

Synonyms:MEC/CCL28,CCK1, MEC, SCYA28, Human

Endotoxin:Less than 1 EU/μg of rHuMEC/CCL28 as determined by LAL method.

Storage:-20ºC

Sequence:SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY

uniprot accession:Q9NRJ3

Molecular weight:Approximately 12.4 kDa, a single non-glycosylated polypeptide chain containing 18 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 13 mM NaCl.