Recombinant Human MCP-4/CCL13 protein

SKU: CD01313

Size:5 ug

Background:Human CCL13 is belonging to the CC chemokine family and is encoded by the gene CCL13 in humans. CCL13 (MCP-4) shares 56-61 % sequence identity with MCP-1 (CCL2) and MCP-3 (CCL7) and is 60 % identical to Eotaxin (CCL11). CCL13 was a potent chemoattractant for monocytes and eosinophils and stimulated histamine release from basophils. CCL13 can induce a calcium flux in HEK-293 cells transfected with the receptor CCR2B and CCR3. That shows the function receptors of CCL3 are CCR2B and CCR3.

Research_area:Immunology

Purity:> 96 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Monocyte Chemotactic Protein-4/CCL13

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 1-1 ng/ml.

Synonyms:MCP-4/CCL13, CKb1, MCP-4, NCC-1, NCC1, SCYA13, SCYL1,Human

Endotoxin:Less than 1 EU/μg of rHuMCP-4/CCL13 as determined by LAL method.

Storage:-20ºC

Sequence:QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT

uniprot accession:Q99616

Molecular weight:Approximately 8.6 kDa, a single non-glycosylated polypeptide chain containing 75 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 13 mM NaCl.