Recombinant Human Kallikrein 2/KLK2 Protein (His Tag)

SKU: PKSH032666

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: Kallikrein 2;KLK2

Target Synonym: Glandular Kallikrein-1;KLK2;Kallikrein-2;Tissue Kallikrein-2;hGK-1

Research Areas: Signal Transduction;Cell biology;Cancer;

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: P20151

Accession: P20151

Background: Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.

Concentration:

Activity: Not validated for activity

Sequence: Pro19-Pro261

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Acetate, 250mM Trehalose, 0.02% Tween 80, pH5.0.

Reconstitution: Not Applicable

Endotoxin: < 0.01 EU per μg of the protein as determined by the LAL method.

Calculated MW: 27.9 kDa

ObservedMW: 10-12&16-19&28-33 kDa