Recombinant Human Eotaxin/CCL11 protein

SKU: CD01867

Size:5 ug

Background:Human CCL11 is belonging to the CC chemokine family. It is encoded by the gene CCL11. CCL11 was first purified from bronchoalveolar lavage fluid of guinea pigs. It was a strong and specific eosinophil chemoattractant in vitro. It can directly chemotactic for eosinophils, but not for monocytes or neutrophils. Human CCL11 is approximately 63 % identical at the amino acid level to Mouse CCL11. In addition, CCL11 also shows about 60 % amino acid sequence identity to human MCPs. CCR3 has been identified to be a specific CCL11 receptor.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Eotaxin/CCL11

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of .1-1. ng/ml.

Synonyms:Eotaxin/CCL11, SCYA11,Human

Endotoxin:Less than 1 EU/μg of rHuEotaxin/CCL11 as determined by LAL method.

Storage:-20ºC

Sequence:GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDICADPKKKWVQD SMKYLDQKSP TPKP

uniprot accession:P51671

Molecular weight:Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 15 mM NaCl.