Recombinant Human CEACAM-1/CD66a Protein(Fc Tag)

SKU: PDMH100298

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Immune Checkpoint Proteins

Abbreviation:CEACAM-1/CD66a

Target Synonym:Biliary Glycoprotein;Carcinoembryonic Antigen-Related Cell Adhesion Molecule;CEACAM;CEACAM1;BGP;BGP1;BGPI;BGP-1;Biliary Glycoprotein 1;Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1;CD66a; NCA-160;Antigen CD66;BGP 1;Biliary glycoprotein adhesion molecule;Carcinoembryonic antigen related cell adhesion molecule 1;carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein);CD66a antigen;CEAM1;meconium antigen 100

Research Areas:Tags & Cell Markers;Immunology;Cancer;Microbiology

Conjugation:

Target Species:Human

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:P13688

Accession:P13688

Background:The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1 , also known as biliary glycoprotein I (BGP I) and CD66a , is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD , and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells , epithelial cells , and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners , and was detected on leukocytes , epithelia , and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation , angiogenesis , apoptosis , metastasis , as well as the modulation of innate and adaptive immune responses.

Concentration:

Activity:Not validated for activity

Sequence:Gln35-Gly428

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:68.2 kDa

ObservedMW:90-100 kDa