Recombinant Human BMP-4 protein

SKU: CD02240

Size:2 ug

Background:Bone Morphogenetic Protein 4 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-4 is expressed in the lung and lower levels seen in the kidney. It also presents in normal and neoplastic prostate tissues, and prostate cancer cell lines. It regulates the formation of teeth, limbs and bone from mesoderm. Furthermore it also plays a role in fracture repair. BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans. The human BMP-4 shares 98 % sequence indentity with mouse BMP-4. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Bone Morphogenetic Protein 4

Biological activity:Data is not available.

Synonyms:BMP-4, BMP4,BMP2B, BMP2B1, MCOPS6, OFC11, ZYME,Human

Endotoxin:Less than 1 EU/μg of rHuBMP-4 as determined by LAL method.

Storage:-20ºC

Sequence:MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR

uniprot accession:P12644

Molecular weight:Approximately 13.3 kDa, a monomeric, non-glycosylated polypeptide chain containing 117 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 5 mM Na2CO3, 5 mM DTT, pH 11..