Recombinant GLUT3+GLUT14 Monoclonal Antibody

SKU: AN301929L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:GLUT3+GLUT14

Target Synonym:GTR;Solute carrier family;Glucose transporter type;facilitated glucose transporter member;Solute Carrier Family 2 (Facilitated Glucose Transporter) Member;SLC2A;SLC2A3;GLUT3;facilitated glucose transporter member 3;FLJ90380;Glucose transporter type 3;Glucose transporter type 3 brain;GLUT 3;GLUT-3;GTR3;Solute carrier family 2;Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3;brain

Research Areas:Signal Transduction;Cell Biology;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A645

UNIProt ID:P11169

Accession:

Background:A group of related glucose transporters (Glut1-5 and 7) mediate the facilitated diffusion of glucose in nonepithelial mammalian tissues. Glucose transporter 3 (Glut3), also known as SLC2A3, has a higher affinity for glucose than the ubiquitous glucose transporter Glut1. In the normal brain, Glut3 expression is limited to neurons, whereas Glut1 is expressed in both neurons and glia. Glioblastoma-derived brain tumor initiating cells (BTICs) express increased levels of Glut3, enabling their survival in the microenvironment deficient in glucose. In addition, Glut3 expression levels correlate with poor survival in brain tumors. Glucose transporter 4 (Glut4) is a 12-transmembrane domain protein that facilitates glucose transport in the direction of the glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation. Translocation of Glut4 is dependent on Akt, which may act by phosphorylating AS160, a RabGAP protein involved in membrane trafficking.The antibody can detect both GLUT3 and GLUT4.

Concentration:1 mg/mL

Immunogen:Recombinant human GLUT3+GLUT14 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000

Calculated MW:54 kDa

ObservedMW:54 kDa