Recombinant ER alpha/ESR1 Monoclonal Antibody

SKU: AN300296P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:ESR1

Target Synonym:NR3A;nuclear receptor subfamily;Nuclear Receptor Subfamily 3 Group A Member;member;ESR1;ER;ESR;ESRA;ESTRR;Era;NR3A1;ER alpha;ER-Alpha;Estradiol Receptor;Estrogen Receptor;Estrogen Receptor α;group A;member 1;nuclear receptor subfamily 3;Nuclear Receptor Subfamily 3 Group A Member 1;7*/654 isoform;7*/819 2 isoform;7*/822 isoform;8*/901 isoform;8*/941 isoform;DKFZp686N23123;Estrogen nuclear receptor alpha;Estrogen receptor 1;Estrogen receptor alpha;Estrogen receptor alpha 3*;Estrogen receptor alpha delta 3*;Estrogen receptor alpha delta 4 +49 isoform;Estrogen receptor alpha E1 E2 1 2;Estrogen receptor alpha E1 N2 E2 1 2

Research Areas:Signal Transduction;Neuroscience;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Monoclonal

Clone NO.:3P11

UNIProt ID:P03372

Accession:

Background:This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Concentration:1 mg/mL

Immunogen:A synthetic peptide corresponding to the center region of the Human ER alpha/ESR1

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000

Calculated MW:66 kDa

ObservedMW:79 kDa