Recombinant ClC-2 Monoclonal Antibody

SKU: AN301722L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:ClC-2

Target Synonym:CIC;CLCN;EJM;EGI;CLC;ECA;CLCN2;CIC-2;CLC2;ECA2;ECA3;EGI11;EGI3;EGMA;EJM6;EJM8;LKPAT;clC-2

Research Areas:Neuroscience;Signal Transduction;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A430

UNIProt ID:P51788

Accession:

Background:ClC-2 (chloride channel protein 2) is a transmembrane protein and functions as a voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. ClC-2 is highly expressed in adrenal gland and involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis. Defects in this gene may be a cause of certain epilepsies.

Concentration:1 mg/mL

Immunogen:Recombinant human ClC-2 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100

Calculated MW:99 kDa

ObservedMW:94/99 kDa