Recombinant CDK4 Monoclonal Antibody

SKU: AN300936L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Cdk4

Target Synonym:Crk;MGC;Cell division kinase;cyclin-dependent kinase;Cyclin dependent kinase;Cell division protein kinase;Melanoma cutaneous malignant;PSK-J;PSK J;p34 cdk;CMM;CDK;CDK4;CMM3;PSK-J3;cyclin-dependent kinase 4;Cdk 4;CDK4 protein;Cell division kinase 4;Cell division protein kinase 4;CMM 3;Crk3;Cyclin dependent kinase 4;Melanoma cutaneous malignant 3;MGC14458;p34 cdk4;PSK J3;CMM3;cyclin-dependent kinase 4;PSK-J3

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer;Isotype;Loading Controls

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:7A9

UNIProt ID:P11802

Accession:

Background:CDK4(cyclin dependent kinase 4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human CDK4 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000;

Calculated MW:34 kDa

ObservedMW:34 kDa