Recombinant CD23/FCER2 Monoclonal Antibody

SKU: AN300547P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:FCER2

Target Synonym:Fce;FCER;CD23;Fce2;Fc-epsilon-RII;Ly-42;Lymphocyte IgE receptor;Fcer2a;Fcer2;Fc&epsilon-RII-I;Ly-42;BLAST-2;CD23A;CLEC4J;Fc epsilon RII;IGEBF

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse

Application:FCM;ICC/IF

Isotype:IgG

Clonality:Monoclonal

Clone NO.:4F9

UNIProt ID:P20693

Accession:

Background:CD23, also known as FcεRII, is a trimeric type II transmembrane glycoprotein member of the calcium-dependent (C-type) lectin family. CD23 is expressed in B and T lymphocytes, monocytes, polymorphonuclear leukocytes, follicular dendritic cells, intestinal epithelial cells, and bone marrow stromal cells. CD23 was first identified as a low-affinity receptor for IgE and the engagement of membrane bound CD23 leads to suppressed IgE production by B lymphocytes. CD23 can be cleaved to form a soluble protein which can drive cytokine release in monocytic cells, nitric oxide (NO) production, and the synthesis of cyclic adenosine 3′5′-monophosphate (cAMP). Soluble CD23 signals through integrins, activating MAPK and NF-κB pathways. CD23 is a useful marker in the prognosis of neoplastic disease, is elevated in a variety of autoimmune and inflammatory conditions, and is being investigated as a therapeutic target for IgE-mediated allergy, arthritis, and B cell chronic lymphocytic leukemia (CLL).

Concentration:1 mg/mL

Immunogen:Recombinant Mouse CD23/FCER2 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100;FCM 1:25-1:100

Calculated MW:

ObservedMW: