Recombinant Bim Monoclonal Antibody

SKU: AN300812L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Bim

Target Synonym:Bcl-2-like protein;BCL2L;Bcl2-L;BAM;BIM;BOD;BCL2L11;Bcl2-interacting mediator of cell death;Bcl2-L-11;Bcl-2-like protein 11;BIML;BimEL

Research Areas:Cell Biology;Neuroscience;Immunology;Signal Transduction;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:4B11

UNIProt ID:O43521

Accession:

Background:The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Bim protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000;IHC 1:200-1:1000

Calculated MW:22 kDa

ObservedMW:22 kDa