Recombinant APC Monoclonal Antibody

SKU: E-AB-81529

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:APC

Target Synonym:Adenomatous Polyposis Coli;Adenomatous polyposis coli protein;Apc;APC;CC1;Deleted in polyposis 2.5;DP2;DP2.5;DP3;FAP;FPC;GS;Protein APC

Research Areas:Cancer;Cell Biology;Cardiovascular;Epigenetics and Nuclear Signaling;Neuroscience;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:R06-2E4

UNIProt ID:P25054

Accession:

Background:This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Concentration:300 μg/mL

Immunogen:A synthetic peptide of human APC

Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Purification method:Affinity Purified

Dilution:WB 1:500-1:1000

Calculated MW:312kDa

ObservedMW:160kDa