Rat TYRO Protein Tyrosine Kinase-Binding Protein ,TYROBP;DAP12 ELISA KIT

SKU: E2636Ra

Size:96 Tests-1 Kit

Background:Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). PAssociation with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes proinflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). ositively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). {ECO:0000250|UniProtKB:O43914, ECO:0000250|UniProtKB:O54885}.

Research_area:

Applications:ELISA

Target_protein:Tyrobp

Reactivity:Rat

Assay type:Sandwich

Sensitivity:10.17ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:TYRO Protein Tyrosine Kinase-Binding Protein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6X9T7

MASS(Da):12361

GeneID:361537

Synonyms:Tyrobp Dap12

Gene names:Tyrobp

Standard solution:4800ng/L