Rat Transcription Factor A, Mitochondrial, TFAM ELISA Kit

SKU: E1616Ra

Size:96 Tests-1 Kit

Background:[Isoform Mitochondrial]: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA (By similarity). [Isoform Nuclear]: May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis.

Research_area:Others

Applications:ELISA

Target_protein:TFAM

Reactivity:Rat

Assay type:Sandwich

Sensitivity:3.52ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription Factor A,Mitochondrial

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q91ZW1

MASS(Da):28,187

GeneID:83474

Synonyms:mtTFA;TFAM;Transcription factor A, mitochondrial

Gene names:TFAM

Standard solution:1600ng/L