Rat Solute Carrier Family 22 Member 1, SLC22A1 ELISA Kit

SKU: E2334Ra

Size:96 Tests-1 Kit

Background:Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:SLC22A1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:11.39ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Solute carrier family 22 member 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q63089

MASS(Da):61,541

GeneID:24904

Synonyms:44470;Orct1;Organic cation transporter 1;Roct1;SLC22A1;Solute carrier family 22 member 1

Gene names:Slc22a1

Standard solution:6400ng/L