Rat Signal Transducer and Activator of Transcription 3, STAT3 ELISA Kit

SKU: E2093Ra

Size:96 Tests-1 Kit

Background:Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Research_area:Signal Transduction; Epigenetics and Nuclear Signaling; Stem Cells; Cancer

Applications:ELISA

Target_protein:STAT3

Reactivity:Rat

Assay type:Sandwich

Sensitivity:1.71ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Signal Transducer and Activator of Transcription 3

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P52631

MASS(Da):88,040

GeneID:25125

Synonyms:Signal transducer and activator of transcription 3;STAT 3;STAT3

Gene names:STAT3

Standard solution:960ng/L