Rat Serine, Threonine-protein Kinase Tao2, TAOK2 ELISA Kit

SKU: E2606Ra

Size:96 Tests-1 Kit

Background:Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation.

Research_area:Others

Applications:ELISA

Target_protein:TAOK2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:7.33ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Serine,threonine-protein kinase TAO2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9JLS3

MASS(Da):138,751

GeneID:64666

Synonyms:Serine/threonine-protein kinase TAO2;Tao2;TAOK2;Thousand and one amino acid protein 2

Gene names:Taok2

Standard solution:3200ng/L