Rat Protein Wnt-5A, WNT5A ELISA Kit

SKU: E2224Ra

Size:96 Tests-1 Kit

Background:Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:WNT5A

Reactivity:Rat

Assay type:Sandwich

Sensitivity:3.47ng/L

Detection range:6-1800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Wnt-5a

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9QXQ7

MASS(Da):42,283

GeneID:64566

Synonyms:Protein Wnt-5a;WNT5A

Gene names:Wnt5a

Standard solution:1920ng/L