Rat Neuronal Cell Adhesion Molecule, NRCAM ELISA Kit

SKU: E2176Ra

Size:96 Tests-1 Kit

Background:Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons (By similarity). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Research_area:Neuroscience

Applications:ELISA

Target_protein:NRCAM

Reactivity:Rat

Assay type:Sandwich

Sensitivity:9.67ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Neuronal cell adhesion molecule

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P97686

MASS(Da):133,912

GeneID:497815

Synonyms:Ankyrin-binding cell adhesion molecule NrCAM;Neuronal cell adhesion molecule;Neuronal surface protein Bravo;Ng-CAM-related;NgCAM-related cell adhesion molecule;NRCAM;Nr-CAM;rBravo

Gene names:Nrcam

Standard solution:8000ng/L