Rat Kremen protein 1,KREMEN1 ELISA KIT

SKU: E0959Ra

Size:96 Tests-1 Kit

Background:Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. {ECO:0000250|UniProtKB:Q90Y90, ECO:0000250|UniProtKB:Q99N43}.

Research_area:

Applications:ELISA

Target_protein:Kremen1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Kremen protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q924S4

MASS(Da):51869

GeneID:114107

Synonyms:Kremen1 Kremen

Gene names:Kremen1

Standard solution:24ng/ml