Rat Histidine-proline-rich glycoprotein,HPRG ELISA KIT

SKU: E0927Ra

Size:96 Tests-1 Kit

Background:Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity). {ECO:0000250}.

Research_area:

Applications:ELISA

Target_protein:Hrg

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.25ng/ml

Detection range:0.5-32ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Histidine-proline-rich glycoprotein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99PS8

MASS(Da):59049

GeneID:171016

Synonyms:Hrg Hrg1

Gene names:Hrg

Standard solution:64ng/ml