Rat Eukaryotic Translation Initiation Factor 4E, EIF4E ELISA Kit

SKU: E2608Ra

Size:96 Tests-1 Kit

Background:Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:7939721). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:8558852). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (PubMed:8558852).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:EIF4E

Reactivity:Rat

Assay type:Sandwich

Sensitivity:4.12ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Eukaryotic Translation Initiation Factor 4E

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P63074

MASS(Da):25,053

GeneID:117045

Synonyms:EIF4E;eIF-4E;eIF-4F 25 kDa subunit;Eukaryotic translation initiation factor 4E;mRNA cap-binding protein

Gene names:Eif4e

Standard solution:1600ng/L