Rat Cyclin-D2,CCND2 ELISA KIT

SKU: E0631Ra

Size:96 Tests-1 Kit

Background:Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.

Research_area:

Applications:ELISA

Target_protein:Ccnd2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:17.7pg/ml

Detection range:37.5-2400pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cyclin-D2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q04827

MASS(Da):32826

GeneID:64033

Synonyms:Ccnd2 Vin-1

Gene names:Ccnd2

Standard solution:4800pg/ml