Rat Cyclic AMP-dependent transcription factor ATF-6 alpha,ATF-6 ELISA KIT

SKU: E1524Ra

Size:96 Tests-1 Kit

Background:[Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). {ECO:0000250|UniProtKB:P18850}.; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. {ECO:0000250|UniProtKB:P18850}.

Research_area:

Applications:ELISA

Target_protein:Atf6

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.56ng/ml

Detection range:1-64ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:activating transcription factor 6

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:G3V909

MASS(Da):72665

GeneID:304962

Synonyms:Atf6

Gene names:Atf6

Standard solution:128ng/ml