Rat Cop9 Signalosome Compex Subunit 1, GPS1 ELISA Kit

SKU: E1192Ra

Size:96 Tests-1 Kit

Background:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:GPS1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.03ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cop9 Signalosome Compex Subunit 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P97834

MASS(Da):53,428

GeneID:117039

Synonyms:COP9 signalosome complex subunit 1;G protein pathway suppressor 1;GPS 1;GPS1;GPS-1;JAB1-containing signalosome subunit 1;MFH protein;SGN1;Signalosome subunit 1;

Gene names:GPS1

Standard solution:40ng/ml