Rat Complement C3,C3 ELISA KIT

SKU: E3335Ra

Size:96 Tests-1 Kit

Background:C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. {ECO:0000269|PubMed:8352775}.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils (PubMed:8352775). {ECO:0000269|PubMed:8352775}.; [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000269|PubMed:8352775}.; [Acylation stimulating protein]: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (By similarity). {ECO:0000250}.

Research_area:

Applications:ELISA

Target_protein:C3

Reactivity:Rat

Assay type:Sandwich

Sensitivity:10.02ng/ml

Detection range:18.75-1200ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01026

MASS(Da):186460

GeneID:24232

Synonyms:C3

Gene names:C3

Standard solution:2400ng/ml