Rat Cartilage Oligomeric Matrix Protein, COMP ELISA Kit

SKU: E0533Ra

Size:96 Tests-1 Kit

Background:May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Research_area:Cell Biology

Applications:ELISA

Target_protein:COMP

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.25ng/mL

Detection range:0.5-200ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Cartilage Oligomeric Matrix Protein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35444

MASS(Da):82,664

GeneID:25304

Synonyms:Cartilage oligomeric matrix protein;COMP

Gene names:COMP

Standard solution:240ng/mL