Rat C-C Chemokine Receptor Type 2, CCR2 ELISA Kit

SKU: E1901Ra

Size:96 Tests-1 Kit

Background:Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity) Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:CCR2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:3.35ng/L

Detection range:6-1800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:C-C Chemokine Receptor Type 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O55193

MASS(Da):42,763

GeneID:60463

Synonyms:C-C chemokine receptor type 2;C-C CKR-2;CC-CKR-2;CCR 2;CCR2;CCR-2;CD antigen CD192

Gene names:CCR2

Standard solution:1920ng/L