Rat Bridging Integrator 1,BIN1 ELISA KIT

SKU: E2423Ra

Size:96 Tests-1 Kit

Background:Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:9736607, PubMed:27760323). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). {ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08539, ECO:0000269|PubMed:27760323, ECO:0000269|PubMed:9736607}.

Research_area:

Applications:ELISA

Target_protein:Bin1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.04ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bridging Integrator 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O08839

MASS(Da):64533

GeneID:117028

Synonyms:Bin1 Amph2 Amphl

Gene names:Bin1

Standard solution:2400ng/L