Rat 5-Hydroxytryptamine Receptor 2C, HTR2C ELISA Kit

SKU: E1793Ra

Size:96 Tests-1 Kit

Background:G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium Channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Research_area:Neuroscience

Applications:ELISA

Target_protein:HTR2C

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.016ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:5-Hydroxytryptamine Receptor 2C

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08909

MASS(Da):51,917

GeneID:25187

Synonyms:5-HT1C;5-HT-1C;5-HT2C;5-HT-2C;5-HTR2C;5-hydroxytryptamine receptor 1C;5-hydroxytryptamine receptor 2C;HTR 2C;HTR2C;Serotonin receptor 2C

Gene names:HTR2C

Standard solution:24ng/ml