RAD9A Antibody, FITC conjugated - Cat. #: CSB-PA857455LC01HU

SKU: CSB-PA857455LC01HU

Size :50ug

Clone Number:

Aliases:Cell cycle checkpoint control protein antibody; Cell cycle checkpoint control protein RAD9A antibody; DNA repair exonuclease rad9 homolog A antibody; hRAD 9 antibody; hRAD9 antibody; Rad 9 antibody; RAD 9A antibody; RAD9 (S pombe) homolog antibody; RAD9 homolog A antibody; RAD9 homolog antibody; Rad9a antibody; RAD9A_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q99638

Immunogen:Recombinant Human Cell cycle checkpoint control protein RAD9A protein (267-341AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3\'->5\' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RAD9A

Research Areas:Epigenetics and Nuclear Signaling